Recombinant Mouse IL2 Protein, C-His Tag_天津卡梅德科技发展有限公司

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Recombinant Mouse IL2 Protein, C-His Tag

Recombinant Mouse IL2 Protein, C-His Tag

产品编号

KRP657

别名

白细胞介素-2, Interleukin-2 , IL-2, T-cell growth factor, TCGF, Il-2, Interleukin-2

规格

20ug
50ug
100ug
200ug
1mg

DATASHEET MSDS

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产品介绍

Alias	白细胞介素-2, Interleukin-2 , IL-2, T-cell growth factor, TCGF, Il-2, Interleukin-2
Catalog Number	KRP657
Molecular Name	Il2
Molecular Weight	20kd
Size	20ug, 50ug, 100ug, 200ug, 1mg
Concentration	联系销售经理获得最新批次的浓度
Purity	≥95%
Product Description	Mouse Il2(Ala21-Gln169)
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Formulation	< 0.1 EU per ug
Shipping Condition	This product is shipped on ice packs or dry ice.
Background	Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance (PubMed:14614860, PubMed:9814585). Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5 (PubMed:14614860, PubMed:27018889). This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance (PubMed:14614860). Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells (PubMed:9814585). {ECO:0000250\|UniProtKB:P60568, ECO:0000269\|PubMed:9814585}.
Species	Mouse
Purification	Affinity Purification
Endotoxin	Supplied in PBS
Biological Activity	Measured in a cell proliferation assay using HT-2 mouse T cells. The ED50 for this effect is 0.88-3.5 ng/mL, corresponding to a specific activity of 2.86×105-1.14×106 units/mg.
Uniprot ID	P04351
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。
Display Peptides	HEK293F Cells

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