Recombinant Mouse BMP4 Protein, C-His Tag_天津卡梅德科技发展有限公司

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Recombinant Mouse BMP4 Protein, C-His Tag

Recombinant Mouse BMP4 Protein, C-His Tag

产品编号

KRP226

别名

BMP-4,BMP4,BMP2B,BMP-2B,BMP2B1,Bone morphogenetic protein 4,Bone morphogenetic protein 2B,Bmp-4,Dvr-4

规格

20ug
50ug
100ug
200ug
1mg

DATASHEET COA

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产品介绍

Alias	BMP-4,BMP4,BMP2B,BMP-2B,BMP2B1,Bone morphogenetic protein 4,Bone morphogenetic protein 2B,Bmp-4,Dvr-4
Catalog Number	KRP226
Product Description	Mouse Bmp4(293-408 aa)
Molecular Name	Bmp4
Species	Mouse
Size	20ug, 50ug, 100ug, 200ug, 1mg
Purity	≥95%
Concentration	Contact the sales manager to obtain the concentration of the latest batch.
Purification	Affinity Purification
Endotoxin	< 0.1 EU per ug
Formulation	Supplied in PBS
Background	Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (PubMed:10049358, PubMed:14973287, PubMed:15206957). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (PubMed:17301089). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus (PubMed:34995814). Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling (PubMed:27713059, PubMed:8898217). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (PubMed:29148101). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (PubMed:8898217). Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (By similarity). {ECO:0000250\|UniProtKB:P12644, ECO:0000269\|PubMed:10049358, ECO:0000269\|PubMed:14973287, ECO:0000269\|PubMed:15206957, ECO:0000269\|PubMed:17301089, ECO:0000269\|PubMed:27713059, ECO:0000269\|PubMed:29148101, ECO:0000269\|PubMed:34995814, ECO:0000269\|PubMed:8898217}.
Biological Activity	Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 forthis effect is 5- 40 ng/mL
Storage Condition	开瓶后在-80℃条件下保存12个月，保持无菌状态。冻干粉需存于-20℃环境中。避免反复冻融。
Shipping Condition	此产品采用冰袋或干冰运输。
Molecular Weight	12 kDa
Uniprot ID	P21275
Product Declaration	本产品仅供研究使用，不得直接用于人体或注射。

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