KRP645
唾液酸结合Ig样凝集素7, Sialic acid-binding Ig-like lectin 7 , Siglec-7, Adhesion inhibitory receptor molecule 1, AIRM-1, CDw328, D-siglec, QA79 membrane protein, p75, CD antigen CD328, AIRM1, Sialic acid-binding Ig-like lectin 7
| Catalog Number | KRP645 |
| Alias | 唾液酸结合Ig样凝集素7, Sialic acid-binding Ig-like lectin 7 , Siglec-7, Adhesion inhibitory receptor molecule 1, AIRM-1, CDw328, D-siglec, QA79 membrane protein, p75, CD antigen CD328, AIRM1, Sialic acid-binding Ig-like lectin 7 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human SIGLEC7(19-353 aa) |
| Molecular Name | SIGLEC7 |
| Product Introduction | 唾液酸结合Ig样凝集素7调节免疫细胞的功能，参与免疫逃逸机制。。 |
| Molecular Weight | 50-60 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q9Y286-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269|PubMed:10611343}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by the ability of the immobilized protein to support the adhesion of human red blood cells.The ED50 for this effect is 0.5‑2 µg/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
销售微信
官方公众号
0
