KRP635
E3泛素蛋白连接酶ZNRF3, E3 ubiquitin-protein ligase ZNRF3 , EC 2.3.2.27, RING finger protein 203, RING-type E3 ubiquitin transferase ZNRF3, Zinc/RING finger protein 3, KIAA1133, RNF203, E3 ubiquitin-protein ligase ZNRF3
| Catalog Number | KRP635 |
| Alias | E3泛素蛋白连接酶ZNRF3, E3 ubiquitin-protein ligase ZNRF3 , EC 2.3.2.27, RING finger protein 203, RING-type E3 ubiquitin transferase ZNRF3, Zinc/RING finger protein 3, KIAA1133, RNF203, E3 ubiquitin-protein ligase ZNRF3 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human ZNRF3(56-219 aa) |
| Molecular Name | ZNRF3 |
| Product Introduction | E3泛素蛋白连接酶ZNRF3在蛋白降解中发挥作用，参与细胞信号转导和免疫反应。。 |
| Molecular Weight | 18-27 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE | |
| Purification | Affinity Purification |
| Uniprot ID | Q9ULT6-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity). {ECO:0000250|UniProtKB:Q08D68, ECO:0000269|PubMed:22575959}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its binding ability in a functional ELISA. When Recombinant Human R‑Spondin 3 is coated at 0.25 μg/mL, Recombinant Human ZNRF3 binds with an apparent Kd<3 nM. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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