| Catalog Number | KRP625 |
| Alias | Dickkopf相关蛋白4, Dickkopf-related protein 4 , Dickkopf-4, Dkk-4, hDkk-4, [Cleaved into: Dickkopf-related protein 4 short form], Dickkopf-related protein 4 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human DKK4(19-224 aa) |
| Molecular Name | DKK4 |
| Product Introduction | Dickkopf相关蛋白4在胚胎发育过程中，调节Wnt信号通路，抑制癌症发生。。 |
| Molecular Weight | 35 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Purification | Affinity Purification |
| Uniprot ID | Q9UBT3 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to inhibit Wnt induced TCF reporter activity in HEK293 human embryonic kidney cells. Recombinant Human Dkk-4 inhibits a constant dose of 500 ng/mL of Recombinant Human Wnt-3a. The ED50 forthis effect is 150-900 ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
是的，质量控制检测（如纯度、浓度、功能活性、稳定性等）是确保蛋白质量的关键步骤。
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