| Catalog Number | KRP621 |
| Alias | 白细胞介素-12亚单位β, Interleukin-12 subunit beta , IL-12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL-12 subunit p40, IL12B, Interleukin-12 subunit beta |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Rat Il12b(23-335 aa & 23-215aa) |
| Molecular Name | Il12b |
| Product Introduction | 白细胞介素-12亚单位β在细胞免疫反应中起关键作用，促进T细胞活化。。 |
| Molecular Weight | 42-45 kDa & 26-28 kDa |
| Expression System | HEK293F Cells |
| Species | Rat |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Purification | Affinity Purification |
| Uniprot ID | Q9R278, Q9R103 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. {ECO:0000256|ARBA:ARBA00033720}.; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. {ECO:0000256|ARBA:ARBA00002947, ECO:0000256|RuleBase:RU281113}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured in a cell proliferation assay using PHAactivated mouse splenocytes. The ED50 forthis effect is 0.025- 0.25 ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
是的，重组蛋白可以用于疫苗的开发，特别是在生产抗原性蛋白和研究免疫反应方面。
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