KRP615
白细胞介素-36γ, Interleukin-36 gamma , IL-1-related protein 2, IL-1RP2, Interleukin-1 epsilon, IL-1 epsilon, Interleukin-1 family member 9, IL-1F9, Interleukin-1 homolog 1, IL-1H1, IL1E, IL1F9, IL1H1, IL1RP2, Interleukin-36 gamma
| Alias | 白细胞介素-36γ, Interleukin-36 gamma , IL-1-related protein 2, IL-1RP2, Interleukin-1 epsilon, IL-1 epsilon, Interleukin-1 family member 9, IL-1F9, Interleukin-1 homolog 1, IL-1H1, IL1E, IL1F9, IL1H1, IL1RP2, Interleukin-36 gamma |
| Catalog Number | KRP615 |
| Molecular Name | IL36G |
| Molecular Weight | 17 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Product Description | Human IL36G(18-169 aa) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous pro-inflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in pro-inflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. {ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:20870894, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23095752, ECO:0000269|PubMed:23147407, ECO:0000269|PubMed:24829417}. |
| Species | Human |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Measured by its ability to induce IL-8 secretion in A431 human epithelial carcinoma cells. The ED50 for forthis effect is 1.5-9 ng/mL |
| Uniprot ID | Q9NZH8-1 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | E. coli |
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