KRP602
触发受体表达在髓系细胞1, Triggering receptor expressed on myeloid cells 1 , TREM-1, Triggering receptor expressed on monocytes 1, CD antigen CD354, Triggering receptor expressed on myeloid cells 1 (TREM-1)
| Catalog Number | KRP602 |
| Alias | 触发受体表达在髓系细胞1, Triggering receptor expressed on myeloid cells 1 , TREM-1, Triggering receptor expressed on monocytes 1, CD antigen CD354, Triggering receptor expressed on myeloid cells 1 (TREM-1) |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human TREM1(21-200 aa) |
| Molecular Name | TREM1 |
| Product Introduction | 触发受体表达在髓系细胞1增强免疫反应，参与细胞的激活和炎症反应。。 |
| Molecular Weight | 70 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q9NP99-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | [Isoform 1]: Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102). Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12 (PubMed:17568691, PubMed:25595774, PubMed:29568119). In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma (PubMed:14656437, PubMed:21659545). This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:17098818, PubMed:17568691). By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (PubMed:11323674, PubMed:21393102). {ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:11323674, ECO:0000269|PubMed:14656437, ECO:0000269|PubMed:17098818, ECO:0000269|PubMed:17568691, ECO:0000269|PubMed:21393102, ECO:0000269|PubMed:21659545, ECO:0000269|PubMed:25595774, ECO:0000269|PubMed:29568119}.; [Isoform 2]: Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its ligand. {ECO:0000269|PubMed:26561551}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to block anti-TREM- 1-induced TNFalpha secretion by human peripheral blood mononuclear cells (PBMC). At 1 µg/mL, Recombinant Human TREM‑1 Fc Chimera is able to block > 70% of Goat Anti-Human TREM-1 (20 µg/mL, 200 µL/well) induced T |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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