Canine IL-13 Protein, No tag
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产品编号
KRP599
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别名
白细胞介素-13, Interleukin-13 , IL-13, Interleukin-13 (IL-13)
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KRP599 |
| Alias | 白细胞介素-13, Interleukin-13 , IL-13, Interleukin-13 (IL-13) |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Canine IL13(19-131 aa) |
| Molecular Name | IL13 |
| Product Introduction | 白细胞介素-13通过调节免疫反应，具有抗炎作用，抑制气道炎症。。 |
| Molecular Weight | 10 kDa & 11 kDa |
| Expression System | E. coli |
| Species | Canine |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Purification | Affinity Purification |
| Uniprot ID | Q9N0W9 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cytokine that plays important roles in allergic inflammation and immune response to parasite infection. Synergizes with IL2 in regulating interferon-gamma synthesis. Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (By similarity). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF-alpha through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Also functions on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils. Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6. Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (By similarity). {ECO:0000250|UniProtKB:P20109, ECO:0000250|UniProtKB:P35225, ECO:0000250|UniProtKB:P42203}. |
| Endotoxin | ＜1.0EU/ug |
| Biological Activity | Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 forthis effect is 0.75-3.75 ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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