| Alias | 白细胞介素-22, Interleukin-22 , IL-22, IL-10-related T-cell-derived-inducible factor, IL-TIF, IL-TIF alpha, Interleukin-22a, IL-22a, Il22a, Iltif, Iltifa, |
| Catalog Number | KRP597 |
| Molecular Name | Il22 |
| Molecular Weight | 20 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Product Description | Mouse Il22(34-179 aa) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cytokine that plays a critical role in modulating tissue responses during inflammation (PubMed:33852830, PubMed:35525330). Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage (PubMed:33912578). Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB. Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways. Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN (PubMed:24742671). Promotes epithelial cell spreading (PubMed:24742671). {ECO:0000250|UniProtKB:Q9GZX6, ECO:0000269|PubMed:24742671, ECO:0000269|PubMed:33852830, ECO:0000269|PubMed:33912578, ECO:0000269|PubMed:35525330}. |
| Species | Mouse |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. The ED50 forthis effect is 60-300 pg/mL. |
| Uniprot ID | Q9JJY9 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
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