KRP547
T细胞免疫球蛋白和粘蛋白结构域蛋白4, T-cell immunoglobulin and mucin domain-containing protein 4 , TIMD-4, T-cell immunoglobulin mucin receptor 4, TIM-4, T-cell membrane protein 4, TIM4, T-cell immunoglobulin and mucin domain-containing protein 4
| Alias | T细胞免疫球蛋白和粘蛋白结构域蛋白4, T-cell immunoglobulin and mucin domain-containing protein 4 , TIMD-4, T-cell immunoglobulin mucin receptor 4, TIM-4, T-cell membrane protein 4, TIM4, T-cell immunoglobulin and mucin domain-containing protein 4 |
| Catalog Number | KRP547 |
| Molecular Name | TIMD4 |
| Molecular Weight | 77-90 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Product Description | Human TIMD4(25-314 aa) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways (By similarity). Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:32703939, PubMed:34067457). Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (PubMed:32640697). Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of LKB1/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (By similarity). {ECO:0000250|UniProtKB:Q6U7R4, ECO:0000269|PubMed:32640697, ECO:0000269|PubMed:32703939, ECO:0000269|PubMed:34067457}.; (Microbial infection) Plays a positive role in exosome-mediated trafficking of HIV-1 virus and its entry into immune cells. {ECO:0000269|PubMed:28740388}. |
| Species | Human |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Measured by its ability to inhibit anti-CD3- induced proliferation of stimulated human T cells. The ED50 for this effect is 0.06-0.36 μg/mL. |
| Uniprot ID | Q96H15 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
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