| Catalog Number | KRP535 |
| Alias | 激肽释放酶6, Kallikrein-6 , EC 3.4.21.-, Neurosin, Protease M, SP59, Serine protease 18, Serine protease 9, Zyme, PRSS18, PRSS9, Kallikrein-6 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human KLK6(17-244 aa) |
| Molecular Name | KLK6 |
| Product Introduction | 激肽释放酶6参与神经保护和细胞凋亡过程。。 |
| Molecular Weight | 35 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE | |
| Purification | Affinity Purification |
| Uniprot ID | Q92876-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. {ECO:0000269|PubMed:11983703, ECO:0000269|PubMed:12878203, ECO:0000269|PubMed:12928483, ECO:0000269|PubMed:15557757, ECO:0000269|PubMed:16321973, ECO:0000269|PubMed:16987227}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to cleave the fluorogenic peptide substrate BocQAR-AMC. The specific activity is >1300 pmol/min/µg, as measured underthe described conditions. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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