KRP524
血管紧张素转化酶2, Angiotensin-converting enzyme 2 , EC 3.4.17.23, ACE-related carboxypeptidase, EC 3.4.17.-, [Cleaved into: Processed angiotensin-converting enzyme 2], Angiotensin-converting enzyme 2
| Alias | 血管紧张素转化酶2, Angiotensin-converting enzyme 2 , EC 3.4.17.23, ACE-related carboxypeptidase, EC 3.4.17.-, [Cleaved into: Processed angiotensin-converting enzyme 2], Angiotensin-converting enzyme 2 |
| Catalog Number | KRP524 |
| Molecular Name | Ace2 |
| Molecular Weight | 110 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Product Description | Mouse Ace2(18-740 aa) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A (By similarity). By cleavage of angiotensin II, may be an important regulator of heart function (PubMed:12075344, PubMed:12967627). By cleavage of angiotensin II, may also have a protective role in acute lung injury (PubMed:16001071). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19, regulating its trafficking on the cell surface and its activity (PubMed:18424768, PubMed:19185582, PubMed:22677001). {ECO:0000250|UniProtKB:Q9BYF1, ECO:0000269|PubMed:12075344, ECO:0000269|PubMed:12967627, ECO:0000269|PubMed:16001071, ECO:0000269|PubMed:18424768, ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:22677001}. |
| Species | Mouse |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Immobilized Recombinant Human ACE2 at 2μg/mL (100 μL/well) can bind Recombinant SARS-COV-2 Spike S1 with a linearrange of 0.5-25 ng/mL. |
| Uniprot ID | Q8R0I0 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
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