Recombinant Mouse IL-33 Protein, C-His Tag
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产品编号
KRP500
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别名
白细胞介素-33, Interleukin-33 , IL-33, [Cleaved into: Interleukin-33, 102-266, ; Interleukin-33, 109-266, ], Interleukin-33
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KRP500 |
| Alias | 白细胞介素-33, Interleukin-33 , IL-33, [Cleaved into: Interleukin-33, 102-266, ; Interleukin-33, 109-266, ], Interleukin-33 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Mouse Il33(109-266 aa) |
| Molecular Name | Il33 |
| Product Introduction | 白细胞介素-33通过调节免疫系统，影响免疫反应。。 |
| Molecular Weight | 20-35 kDa |
| Expression System | HEK293F Cells |
| Species | Mouse |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Purification | Affinity Purification |
| Uniprot ID | Q8BVZ5 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:29045903). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines (By similarity). Also involved in activation of mast cells, basophils, eosinophils and natural killer cells (By similarity). Acts as an enhancer of polarization of alternatively activated macrophages (By similarity). Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity). Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (PubMed:34644537). {ECO:0000250|UniProtKB:O95760, ECO:0000269|PubMed:29045903, ECO:0000269|PubMed:34644537}.; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (By similarity). This form is rapidely lost upon angiogenic or pro-inflammatory activation (By similarity). {ECO:0000250|UniProtKB:O95760}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 forthis effect is 0.0125-0.05 ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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