Recombinant Mouse IL-33 Protein, C-His Tag_天津卡梅德科技发展有限公司

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Recombinant Mouse IL-33 Protein, C-His Tag

Recombinant Mouse IL-33 Protein, C-His Tag

产品编号

KRP500

别名

白细胞介素-33, Interleukin-33 , IL-33, [Cleaved into: Interleukin-33, 102-266, ; Interleukin-33, 109-266, ], Interleukin-33

规格

20ug
50ug
100ug
200ug
1mg

DATASHEET MSDS

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产品介绍

Alias	白细胞介素-33, Interleukin-33 , IL-33, [Cleaved into: Interleukin-33, 102-266, ; Interleukin-33, 109-266, ], Interleukin-33
Catalog Number	KRP500
Molecular Name	Il33
Molecular Weight	20-35 kDa
Size	20ug, 50ug, 100ug, 200ug, 1mg
Concentration	联系销售经理获得最新批次的浓度
Purity	≥95%
Product Description	Mouse Il33(109-266 aa)
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Formulation	< 0.1 EU per ug
Shipping Condition	This product is shipped on ice packs or dry ice.
Background	Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:29045903). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines (By similarity). Also involved in activation of mast cells, basophils, eosinophils and natural killer cells (By similarity). Acts as an enhancer of polarization of alternatively activated macrophages (By similarity). Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity). Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (PubMed:34644537). {ECO:0000250\|UniProtKB:O95760, ECO:0000269\|PubMed:29045903, ECO:0000269\|PubMed:34644537}.; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (By similarity). This form is rapidely lost upon angiogenic or pro-inflammatory activation (By similarity). {ECO:0000250\|UniProtKB:O95760}.
Species	Mouse
Purification	Affinity Purification
Endotoxin	Supplied in PBS
Biological Activity	Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 forthis effect is 0.0125-0.05 ng/mL.
Uniprot ID	Q8BVZ5
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。
Display Peptides	HEK293F Cells

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