KRP498
连接粘附分子样, Junctional adhesion molecule-like , Adhesion molecule interacting with CXADR antigen 1, Dendritic cell-specific protein CREA7-1, AMICA1, UNQ722/PRO1387, Junctional adhesion molecule-like
| Alias | 连接粘附分子样, Junctional adhesion molecule-like , Adhesion molecule interacting with CXADR antigen 1, Dendritic cell-specific protein CREA7-1, AMICA1, UNQ722/PRO1387, Junctional adhesion molecule-like |
| Catalog Number | KRP498 |
| Molecular Name | JAML |
| Molecular Weight | 43 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥90% |
| SDS-PAGE |  |
| Product Description | Human JAML(10-265 aa) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. {ECO:0000269|PubMed:12869515, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:18948633, ECO:0000269|PubMed:19064666}. |
| Species | Human |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Measured by the ability of the immobilized protein to support the adhesion of BT‑20 human breast cancer cells. When 5 x 10^4 cells/well are added to rhJAML coated plates (10 µg/mL, 100 µL/well), approximately 55%-75% will adhere after 1 hour at 37° C. Sim |
| Uniprot ID | Q86YT9 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
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