Recombinant Human RSPO2 Protein, C-His Tag_天津卡梅德科技发展有限公司

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Recombinant Human RSPO2 Protein, C-His Tag

Recombinant Human RSPO2 Protein, C-His Tag

产品编号

KRP489

别名

R-spondin-2, R-spondin-2 , Roof plate-specific spondin-2, hRspo2, UNQ9384/PRO34209, R-spondin-2

规格

20ug
50ug
100ug
200ug
1mg

DATASHEET MSDS

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产品介绍

Alias	R-spondin-2, R-spondin-2 , Roof plate-specific spondin-2, hRspo2, UNQ9384/PRO34209, R-spondin-2
Catalog Number	KRP489
Molecular Name	RSPO2
Molecular Weight	25-29 kDa
Size	20ug, 50ug, 100ug, 200ug, 1mg
Concentration	联系销售经理获得最新批次的浓度
Purity	≥95%
Product Description	Human RSPO2(22-205 aa)
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Formulation	< 0.1 EU per ug
Shipping Condition	This product is shipped on ice packs or dry ice.
Background	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720). {ECO:0000269\|PubMed:21727895, ECO:0000269\|PubMed:21909076, ECO:0000269\|PubMed:22615920, ECO:0000269\|PubMed:29769720}.
Species	Human
Purification	Affinity Purification
Endotoxin	Supplied in PBS
Biological Activity	Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells. The typical ED50 is 0.7-2.8 ng/mL in the presence of 5 ng/mL recombinant mouse Wnt-3a.
Uniprot ID	Q6UXX9-1
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。
Display Peptides	HEK293F Cells

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