Recombinant Human GFR alpha-like Protein, C-His Tag_天津卡梅德科技发展有限公司

Recombinant Human GFR alpha-like Protein, C-His Tag

产品编号

KRP488

别名

GDNF家族受体alpha样, GDNF family receptor alpha-like, C6orf144, UNQ9356/PRO34128, GDNF family receptor alpha-like

规格

20ug
50ug
100ug
200ug
1mg

DATASHEET MSDS

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产品介绍

Catalog Number	KRP488
Alias	GDNF家族受体alpha样, GDNF family receptor alpha-like, C6orf144, UNQ9356/PRO34128, GDNF family receptor alpha-like
Size	20ug, 50ug, 100ug, 200ug, 1mg
Product Description	Human GFRAL(19-351 aa)
Molecular Name	GFRAL
Product Introduction	GDNF家族受体alpha样通过参与细胞生长与免疫反应，促进神经修复。。
Molecular Weight	40-45 kDa
Expression System	HEK293F Cells
Species	Human
Concentration	联系销售经理获得最新批次的浓度
Purity	≥95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	Q6UXV0
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Formulation	Supplied in PBS
Shipping Condition	This product is shipped on ice packs or dry ice.
Background	Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:36630958). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:36630958). The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin (PubMed:32661391). Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways (PubMed:31535977, PubMed:32661391). Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (By similarity). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (PubMed:32661391). {ECO:0000250\|UniProtKB:Q6SJE0, ECO:0000269\|PubMed:28846097, ECO:0000269\|PubMed:28846098, ECO:0000269\|PubMed:28846099, ECO:0000269\|PubMed:28953886, ECO:0000269\|PubMed:31535977, ECO:0000269\|PubMed:32661391, ECO:0000269\|PubMed:36630958}.
Endotoxin	< 0.1 EU per ug
Biological Activity	Immobilized Human GFRAL, His Tag at 0.5μg/ml (100μl/Well). Dose response curve for Human GDF15, hFc Tag with the EC50 of 9.4ng/ml.
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。