| Catalog Number | KRP482 |
| Alias | IgG受体FcRn大亚单位p51, IgG receptor FcRn large subunit p51 , IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, IgG receptor FcRn large subunit p51 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Mouse Fcgrt(22-301 aa) |
| Molecular Name | Fcgrt |
| Product Introduction | IgG受体FcRn大亚单位p51通过与IgG Fc片段结合，调节抗体的分布。。 |
| Molecular Weight | 45-47 kDa |
| Expression System | HEK293F Cells |
| Species | Mouse |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q6PKB0 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation. In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB. {ECO:0000256|ARBA:ARBA00046029}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its binding ability in a functional ELISA. When Recombinant Mouse FCRN is immobilized at 0.5 μg/mL (100 μL/well), the concentration of human IgG that produces 50% of the optimal binding response is found to be approximately 2- 10 μg/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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