Recombinant Mouse IL-17A Protein, C-His Tag_天津卡梅德科技发展有限公司

Recombinant Mouse IL-17A Protein, C-His Tag

产品编号

KRP469

别名

白细胞介素17A, Interleukin-17A , IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, Ctla8, Il17, Interleukin-17A

规格

20ug
50ug
100ug
200ug
1mg

DATASHEET MSDS

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产品介绍

Catalog Number	KRP469
Alias	白细胞介素17A, Interleukin-17A , IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, Ctla8, Il17, Interleukin-17A
Size	20ug, 50ug, 100ug, 200ug, 1mg
Product Description	Mouse Il17a(26-158 aa)
Molecular Name	Il17a
Product Introduction	白细胞介素17A通过调节免疫反应，参与抗肿瘤免疫反应。。
Molecular Weight	16-24 kDa
Expression System	HEK293F Cells
Species	Mouse
Concentration	联系销售经理获得最新批次的浓度
Purity	≥95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	Q62386
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Formulation	Supplied in PBS
Shipping Condition	This product is shipped on ice packs or dry ice.
Background	Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:18025225, PubMed:19144317, PubMed:26431948). Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16200068, PubMed:17911633, PubMed:19144317, PubMed:26431948). Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (PubMed:18025225). In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines (PubMed:18025225, PubMed:27923703). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (PubMed:18157131). Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance (PubMed:17372004, PubMed:20364087, PubMed:28709803). Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation (PubMed:17470641, PubMed:23255360). Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis (PubMed:26431948). As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release (PubMed:28709803). In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed:19144317). Involved in antiviral host defense through various mechanisms (PubMed:21946434, PubMed:26735852, PubMed:27795421). Enhances immunity against West Nile virus by promoting T cell cytotoxicity (PubMed:27795421). May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung (PubMed:21946434). Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (PubMed:26735852). {ECO:0000269\|PubMed:16200068, ECO:0000269\|PubMed:17372004, ECO:0000269\|PubMed:17470641, ECO:0000269\|PubMed:17911633, ECO:0000269\|PubMed:18025225, ECO:0000269\|PubMed:18157131, ECO:0000269\|PubMed:19144317, ECO:0000269\|PubMed:20364087, ECO:0000269\|PubMed:21946434, ECO:0000269\|PubMed:23255360, ECO:0000269\|PubMed:26431948, ECO:0000269\|PubMed:26735852, ECO:0000269\|PubMed:27795421, ECO:0000269\|PubMed:27923703, ECO:0000269\|PubMed:28709803}.
Endotoxin	< 0.1 EU per ug
Biological Activity	Immobilized Mouse IL- 17A/CTLA-8 at 2 μg/mL (100 μL/well) can bind Mouse IL- 17RA/CD217 with a linearrange of 0.1-26 ng/mL.
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。