KRP467
TGF-β受体类型2, TGF-beta receptor type-2 , TGFR-2, EC 2.7.11.30, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II, TGF-beta receptor type-2
| Catalog Number | KRP467 |
| Alias | TGF-β受体类型2, TGF-beta receptor type-2 , TGFR-2, EC 2.7.11.30, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II, TGF-beta receptor type-2 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Mouse Tgfbr2(Ile24 -Asp184(Isoform2)) |
| Molecular Name | Tgfbr2 |
| Product Introduction | TGF-β受体类型2通过影响TGF-β信号传导，参与细胞增殖与分化。。 |
| Molecular Weight | 66 kDa |
| Expression System | HEK293F Cells |
| Species | Mouse |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE | |
| Purification | Affinity Purification |
| Uniprot ID | Q62312-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity). {ECO:0000250|UniProtKB:P37173}.; [Isoform RII-1]: Has transforming growth factor beta-activated receptor activity. {ECO:0000250|UniProtKB:P37173}.; [Isoform RII-2]: Has transforming growth factor beta-activated receptor activity. {ECO:0000250|UniProtKB:P37173}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to inhibit TGF-beta 1 activity on HT‑2 mouse T cells. The ED50 forthis effect is 3-10 ng/mL in the presence of 1 ng/mL ofrhTGFbeta 1. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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