Recombinant Mouse CD47 Protein, C-His Tag_天津卡梅德科技发展有限公司

Recombinant Mouse CD47 Protein, C-His Tag

产品编号

KRP464

别名

白细胞表面抗原CD47, Leukocyte surface antigen CD47 , Integrin-associated protein, IAP, CD antigen CD47, Leukocyte surface antigen CD47

规格

20ug
50ug
100ug
200ug
1mg

DATASHEET MSDS

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产品介绍

Catalog Number	KRP464
Alias	白细胞表面抗原CD47, Leukocyte surface antigen CD47 , Integrin-associated protein, IAP, CD antigen CD47, Leukocyte surface antigen CD47
Size	20ug, 50ug, 100ug, 200ug, 1mg
Product Description	Mouse Cd47(19-158 aa)
Molecular Name	Cd47
Product Introduction	白细胞表面抗原CD47通过水解糖蛋白，调节细胞黏附与信号传递。。
Molecular Weight	34-44 kDa
Expression System	HEK293F Cells
Species	Mouse
Concentration	联系销售经理获得最新批次的浓度
Purity	≥90%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	Q61735
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Formulation	Supplied in PBS
Shipping Condition	This product is shipped on ice packs or dry ice.
Background	Adhesive protein that mediates cell-to-cell interactions (By similarity). Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (By similarity). Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:20610415, PubMed:23591719, PubMed:27742621). Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed:27742621). Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (PubMed:20610415). Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (By similarity). Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (PubMed:15917238). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764). In response to THBS1, negatively modulates wound healing (PubMed:18156939). Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (PubMed:23591719). May play a role in membrane transport and/or integrin dependent signal transduction (By similarity). May prevent premature elimination of red blood cells (PubMed:10856220). {ECO:0000250\|UniProtKB:P97829, ECO:0000250\|UniProtKB:Q08722, ECO:0000269\|PubMed:10856220, ECO:0000269\|PubMed:15917238, ECO:0000269\|PubMed:18156939, ECO:0000269\|PubMed:20610415, ECO:0000269\|PubMed:23591719, ECO:0000269\|PubMed:27742621, ECO:0000269\|PubMed:32679764}.
Endotoxin	< 0.1 EU per ug
Biological Activity	Measured by its binding ability in a functional ELISA. When Recombinant Mouse SIRP alpha /CD172a Fc Chimera is coated at 2 μg/mL, Recombinant Mouse CD47 binds with an apparent Kd <0.6 nM. Also measured by its ability to antagonize mouse red blood cell adh
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。