| Catalog Number | KRP456 |
| Alias | 酪氨酸蛋白激酶Mer, Tyrosine-protein kinase Mer , EC 2.7.10.1, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, Mer, Tyrosine-protein kinase Mer |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Mouse Mertk(Glu23 - Phe498) |
| Molecular Name | Mertk |
| Product Introduction | 酪氨酸蛋白激酶Mer通过调节神经发育，影响神经系统的功能。。 |
| Molecular Weight | 110-115 kDa |
| Expression System | HEK293F Cells |
| Species | Mouse |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Purification | Affinity Purification |
| Uniprot ID | Q60805 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:19117932, ECO:0000269|PubMed:20363878}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its binding ability in a functional ELISA. Immobilized rmMer/Fc Chimera at 10 µg/mL (100 µL/well) can bind rhGas6 with a linear range of 0.03-1 µg/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
是的，重组蛋白可以用于疫苗的开发，特别是在生产抗原性蛋白和研究免疫反应方面。
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