KRP440
Meprin A亚单位beta, Meprin A subunit beta , EC 3.4.24.63, Endopeptidase-2, Meprin B, N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta, PABA peptide hydrolase, PPH beta, Meprin A subunit beta
| Catalog Number | KRP440 |
| Alias | Meprin A亚单位beta, Meprin A subunit beta , EC 3.4.24.63, Endopeptidase-2, Meprin B, N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta, PABA peptide hydrolase, PPH beta, Meprin A subunit beta |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human MEP1B(Leu21-Ser593 & Thr23-Ser593) |
| Molecular Name | MEP1B |
| Product Introduction | Meprin A亚单位beta通过水解底物，调节细胞外基质的重塑过程。。 |
| Molecular Weight | 85 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q16820 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. Also cleaves the amyloid precursor protein/APP, thereby releasing neurotoxic amyloid beta peptides (PubMed:27180357). {ECO:0000269|PubMed:21693781, ECO:0000269|PubMed:27180357}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to cleave a fluorogenic peptide substrate, McaSEVNLDAEFRK(Dpn)RRNH2. The specific activity is >350 pmol/min/µg, as measured underthe described conditions. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
可以使用ELISA、Western blot或免疫沉淀等技术来检测蛋白与特定抗体的结合反应性。
使用温和的纯化条件、优化缓冲液成分和减少操作步骤，可以有效减少蛋白的损失。
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