Recombinant Human CD226 Protein, C-hFc and His tag
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产品编号
KRP431
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别名
CD226抗原, CD226 antigen , DNAX accessory molecule 1, DNAM-1, CD antigen CD226, DNAM1, CD226 antigen
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KRP431 |
| Alias | CD226抗原, CD226 antigen , DNAX accessory molecule 1, DNAM-1, CD antigen CD226, DNAM1, CD226 antigen |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human CD226(19-247 aa) |
| Molecular Name | CD226 |
| Product Introduction | CD226抗原在免疫应答中起关键作用，参与细胞间的相互作用。。 |
| Molecular Weight | 80-90 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE | |
| Purification | Affinity Purification |
| Uniprot ID | Q15762 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells (PubMed:8673704, PubMed:9712030). Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells (PubMed:26755705, PubMed:31253644, PubMed:30591568). Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes (By similarity). {ECO:0000250|UniProtKB:Q8K4F0, ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:30591568, ECO:0000269|PubMed:31253644, ECO:0000269|PubMed:8673704, ECO:0000269|PubMed:9712030}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Immobilized Recombinant Human CD226 at 2 μg/mL (100 μL/well) can bind Recombinant Human CD155 with a linearrange of 0.3-1.2 μg/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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