KRP429
Nectin-1, Nectin-1 , Herpes virus entry mediator C, Herpesvirus entry mediator C, HveC, Herpesvirus Ig-like receptor, HIgR, Nectin cell adhesion molecule 1, Poliovirus receptor-related protein 1, CD antigen CD111, HVEC, PRR1, PVRL1, Nectin-1
| Catalog Number | KRP429 |
| Alias | Nectin-1, Nectin-1 , Herpes virus entry mediator C, Herpesvirus entry mediator C, HveC, Herpesvirus Ig-like receptor, HIgR, Nectin cell adhesion molecule 1, Poliovirus receptor-related protein 1, CD antigen CD111, HVEC, PRR1, PVRL1, Nectin-1 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human NECTIN1(Met1-Thr334) |
| Molecular Name | NECTIN1 |
| Product Introduction | Nectin-1通过与疱疹病毒入侵受体结合，调节细胞间的粘附作用。。 |
| Molecular Weight | 80-90 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q15223-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system (PubMed:21325282). Acts by forming homophilic or heterophilic trans-dimers (PubMed:21325282). Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4 (By similarity). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Involved in synaptogegesis (By similarity). Has some neurite outgrowth-promoting activity (By similarity). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN3: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Required for enamel mineralization (By similarity). {ECO:0000250|UniProtKB:Q9JKF6, ECO:0000269|PubMed:21325282}.; (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV (PubMed:21980294, PubMed:25231300, PubMed:28381567, PubMed:28542478, PubMed:34587223, PubMed:38857290, PubMed:39048823, PubMed:39048830, PubMed:7721102, PubMed:9616127, PubMed:9657005). Constitutes the major receptor for herpes simplex virus 1/HHV-1 entry into host cells (PubMed:34587223). {ECO:0000269|PubMed:21980294, ECO:0000269|PubMed:25231300, ECO:0000269|PubMed:28381567, ECO:0000269|PubMed:28542478, ECO:0000269|PubMed:34587223, ECO:0000269|PubMed:38857290, ECO:0000269|PubMed:39048823, ECO:0000269|PubMed:39048830, ECO:0000269|PubMed:7721102, ECO:0000269|PubMed:9616127, ECO:0000269|PubMed:9657005}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Immobilized Recombinant Human Nectin-3 at 2 μg/mL (100 μL/well) can bind Recombinant human Nectin-1 with a linear range of 30-122 ng/mL |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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