KRP423
白细胞介素-11受体亚单位alpha, Interleukin-11 receptor subunit alpha , IL-11 receptor subunit alpha, IL-11R subunit alpha, IL-11R-alpha, IL-11RA, [Cleaved into: Soluble interleukin-11 receptor subunit alpha , sIL-11R, sIL-11RA, sIL11RA, ], Interleukin-11 receptor su
| Catalog Number | KRP423 |
| Alias | 白细胞介素-11受体亚单位alpha, Interleukin-11 receptor subunit alpha , IL-11 receptor subunit alpha, IL-11R subunit alpha, IL-11R-alpha, IL-11RA, [Cleaved into: Soluble interleukin-11 receptor subunit alpha , sIL-11R, sIL-11RA, sIL11RA, ], Interleukin-11 receptor su |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human IL11RA(24-363 aa) |
| Molecular Name | IL11RA |
| Product Introduction | 白细胞介素-11受体亚单位alpha调节免疫反应和骨髓造血过程。。 |
| Molecular Weight | 40-55 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Purification | Affinity Purification |
| Uniprot ID | Q14626 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. {ECO:0000269|PubMed:21741611, ECO:0000305}.; [Soluble interleukin-11 receptor subunit alpha]: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:26876177, PubMed:30279168). The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:26876177, PubMed:30279168). {ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:30279168}.; [Isoform HCR2]: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:26876177, PubMed:30279168). The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:26876177, PubMed:30279168). {ECO:0000269|PubMed:26876177, ECO:0000269|PubMed:30279168}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to bind recombinant human IL-11 in a functional ELISA with an estimated Kd <1 nM |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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