KRP420
骨形态发生蛋白受体类型2, Bone morphogenetic protein receptor type-2 , BMP type-2 receptor, BMPR-2, EC 2.7.11.30, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, PPH1, Bone morphogenetic protein receptor type-2
| Catalog Number | KRP420 |
| Alias | 骨形态发生蛋白受体类型2, Bone morphogenetic protein receptor type-2 , BMP type-2 receptor, BMPR-2, EC 2.7.11.30, Bone morphogenetic protein receptor type II, BMP type II receptor, BMPR-II, PPH1, Bone morphogenetic protein receptor type-2 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human BMPR2(27-151 aa) |
| Molecular Name | BMPR2 |
| Product Introduction | 骨形态发生蛋白受体类型2通过调节骨形态发生，促进细胞分化。。 |
| Molecular Weight | 25-38 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q13873-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade (PubMed:12045205). Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA (PubMed:24018044). {ECO:0000250|UniProtKB:O35607, ECO:0000269|PubMed:12045205, ECO:0000269|PubMed:24018044}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Immobilized Human BMPR2 at 1 μg/mL (100 μL/well) can bind Human BMP2 with a linearrange of 0.015-7.4 μg/ml. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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