KRP416
白细胞介素-10受体亚单位alpha, Interleukin-10 receptor subunit alpha , IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CDw210a, Interleukin-10 receptor subunit 1, IL-10R subunit 1, IL-10R1, CD antigen CD210, IL10R, Interleukin-10 receptor subunit alpha
| Catalog Number | KRP416 |
| Alias | 白细胞介素-10受体亚单位alpha, Interleukin-10 receptor subunit alpha , IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CDw210a, Interleukin-10 receptor subunit 1, IL-10R subunit 1, IL-10R1, CD antigen CD210, IL10R, Interleukin-10 receptor subunit alpha |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human IL10RA(22-235 aa) |
| Molecular Name | IL10RA |
| Product Introduction | 白细胞介素-10受体亚单位alpha调节免疫反应，参与免疫细胞的活化与分化。。 |
| Molecular Weight | 60-80 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q13651 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683). {ECO:0000269|PubMed:12133952, ECO:0000269|PubMed:16982608, ECO:0000269|PubMed:26962683}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Immobilized Human IL10 at 2 μg/mL (100 μL/well) can bind Human IL10RA with a linearrange of 0.1-8.7 ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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