KRP388
低密度脂蛋白受体相关蛋白1, Prolow-density lipoprotein receptor-related protein 1 , LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, CD antigen CD91, [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit , LRP-8
| Catalog Number | KRP388 |
| Alias | 低密度脂蛋白受体相关蛋白1, Prolow-density lipoprotein receptor-related protein 1 , LRP-1, Alpha-2-macroglobulin receptor, A2MR, Apolipoprotein E receptor, APOER, CD antigen CD91, [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit , LRP-8 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human LRP1(3332-3779 aa) |
| Molecular Name | LRP1 |
| Product Introduction | 低密度脂蛋白受体相关蛋白1通过影响低密度脂蛋白的受体功能，调节细胞信号。。 |
| Molecular Weight | 100-120 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q07954-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:1702392, PubMed:26142438). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553). Also acts as a receptor for IGFBP3 to mediate cell growth inhibition (PubMed:9252371). {ECO:0000250|UniProtKB:Q91ZX7, ECO:0000269|PubMed:11907044, ECO:0000269|PubMed:12713657, ECO:0000269|PubMed:12888553, ECO:0000269|PubMed:1702392, ECO:0000269|PubMed:26142438, ECO:0000269|PubMed:32296178, ECO:0000269|PubMed:9252371}.; (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. {ECO:0000269|PubMed:1618748}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its binding ability in a functional ELISA. When Recombinant Human LRP-1 Cluster IV Fc Chimera is immobilized at 50 ng/mL (100 µL/well), Recombinant Human LRPAP binds with an ED50 of 0.0250-0.350 ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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