KRP385
酪氨酸蛋白激酶受体TYRO3, Tyrosine-protein kinase receptor TYRO3 , EC 2.7.10.1, Tyrosine-protein kinase BYK, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase SKY, Tyrosine-protein kinase TIF, BYK, DTK, RSE, SKY, Tyrosine-protein kin
| Catalog Number | KRP385 |
| Alias | 酪氨酸蛋白激酶受体TYRO3, Tyrosine-protein kinase receptor TYRO3 , EC 2.7.10.1, Tyrosine-protein kinase BYK, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase SKY, Tyrosine-protein kinase TIF, BYK, DTK, RSE, SKY, Tyrosine-protein kin |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human TYRO3(41-428 aa) |
| Molecular Name | TYRO3 |
| Product Introduction | 酪氨酸蛋白激酶受体TYRO3通过酪氨酸激酶信号途径，调节神经和免疫反应。。 |
| Molecular Weight | 90-110 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q06418 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:20546121}.; (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:22156524, ECO:0000269|PubMed:22673088, ECO:0000269|PubMed:25277499}.; (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Immobilized Human Gas6 at 2 μg/mL (100 μL/well) can bind Human TYRO3 with a linearrange of 0.1-5.6 ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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