KRP378
Ephrin类型A受体2, Ephrin type-A receptor 2 , EC 2.7.10.1, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, Tyrosine-protein kinase receptor MPK-5, Tyrosine-protein kinase receptor SEK-2, Eck, Myk2, Sek2, Ephrin type-A receptor 2
| Alias | Ephrin类型A受体2, Ephrin type-A receptor 2 , EC 2.7.10.1, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, Tyrosine-protein kinase receptor MPK-5, Tyrosine-protein kinase receptor SEK-2, Eck, Myk2, Sek2, Ephrin type-A receptor 2 |
| Catalog Number | KRP378 |
| Molecular Name | Epha2 |
| Molecular Weight | 105 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Product Description | Mouse Epha2(22-535aa（AAA82113）) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells (PubMed:29749928). Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:15054110, ECO:0000269|PubMed:16782872, ECO:0000269|PubMed:16849550, ECO:0000269|PubMed:18387945, ECO:0000269|PubMed:18948590, ECO:0000269|PubMed:19299512, ECO:0000269|PubMed:19321667, ECO:0000269|PubMed:29749928}. |
| Species | Mouse |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Measured by its ability to bind Recombinant Mouse Ephrin‑A1 Fc Chimera in a functional ELISA. Immobilized Recombinant Mouse EphA2 Fc Chimera at 2 µg/mL (100 µL/well) can bind Recombinant Mouse Ephrin-A1 Fc Chimera with a linearrange of 0.078-5 ng/mL. Opti |
| Uniprot ID | Q03145 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
销售微信
官方公众号
0
