KRP377
β-1,3-半乳糖基化O-糖基糖蛋白, Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase , EC 2.4.1.102, Core 2 beta-1,6-N-acetylglucosaminyltransferase, C2GlcNAcT, Core 2-branching enzyme, Core2-GlcNAc-transferase, C2GNT, Core 2 GNT, Leuk
| Catalog Number | KRP377 |
| Alias | β-1,3-半乳糖基化O-糖基糖蛋白, Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase , EC 2.4.1.102, Core 2 beta-1,6-N-acetylglucosaminyltransferase, C2GlcNAcT, Core 2-branching enzyme, Core2-GlcNAc-transferase, C2GNT, Core 2 GNT, Leuk |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human GCNT1(33-428 aa) |
| Molecular Name | GCNT1 |
| Product Introduction | β-1,3-半乳糖基化O-糖基糖蛋白通过影响糖基化过程，调节细胞和组织的生物学功能。。 |
| Molecular Weight | 50-57 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q02742 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine (GlcNAc) moiety in beta1-6 linkage from UDP-GlcNAc onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan (PubMed:1329093, PubMed:23027862). The catalysis is metal ion-independent and occurs with inversion of the anomeric configuration of sugar donor (By similarity). Selectively involved in synthesis of mucin-type core 2 O-glycans that serve as scaffolds for the display of selectin ligand sialyl Lewis X epitope by myeloid cells, with an impact on homeostasis and recruitment to inflammatory sites (By similarity). Can also act on glycolipid substrates. Transfers GlcNAc moiety to GalGb4Cer globosides in a reaction step to the synthesis of stage-specific embryonic antigen 1 (SSEA-1) determinant (By similarity). Can use Galbeta1-3GalNAcalpha1- and Galbeta1-3GalNAcbeta1- oligosaccharide derivatives as acceptor substrates (By similarity). {ECO:0000250|UniProtKB:Q09324, ECO:0000269|PubMed:1329093, ECO:0000269|PubMed:23027862}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to transfer GlcNAc from UDPGlcNAc to B1-3 galactosyl-Nacetyl galactosamine. The specific activity is >350 pmol/min/μg, as measured under the described conditions. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
销售微信
官方公众号
0
