KRP371
血管内皮生长因子A, Vascular endothelial growth factor A, long form , L-VEGF, Vascular permeability factor, VPF, [Cleaved into: N-VEGF; VEGFA], Vegf, Vascular endothelial growth factor A
| Alias | 血管内皮生长因子A, Vascular endothelial growth factor A, long form , L-VEGF, Vascular permeability factor, VPF, [Cleaved into: N-VEGF; VEGFA], Vegf, Vascular endothelial growth factor A |
| Catalog Number | KRP371 |
| Molecular Name | Vegfa |
| Molecular Weight | 25-30 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Product Description | Mouse Vegfa(27-190 aa) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | [N-VEGF]: Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A (PubMed:35455969). Involved in protecting cells from hypoxia-mediated cell death (PubMed:35455969). {ECO:0000269|PubMed:35455969}.; [VEGFA]: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:16293765). May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis (By similarity). {ECO:0000250|UniProtKB:P15692, ECO:0000250|UniProtKB:P16612, ECO:0000269|PubMed:16293765, ECO:0000269|PubMed:26503042}. |
| Species | Mouse |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells. The ED50 forthis effect is 0.8-4 ng/mL. |
| Uniprot ID | Q00731-2 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
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