Recombinant Rat IFN-beta Protein, C-His Tag
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产品编号
KRP354
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别名
干扰素β（IFN-β）, Interferon beta , IFN-beta, Ifnb, Interferon beta
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KRP354 |
| Alias | 干扰素β（IFN-β）, Interferon beta , IFN-beta, Ifnb, Interferon beta |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Rat Ifnb1(22-184 aa) |
| Molecular Name | Ifnb1 |
| Product Introduction | 干扰素β（IFN-β）通过调节细胞免疫反应，参与抗病毒和抗肿瘤反应。。 |
| Molecular Weight | 30-38 kDa |
| Expression System | HEK293F Cells |
| Species | Rat |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Purification | Affinity Purification |
| Uniprot ID | P70499 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity). {ECO:0000250|UniProtKB:P01574, ECO:0000250|UniProtKB:P01575}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Interferon was titrated with the use of the cytopathic effect inhibition assay. In this antiviral assay forinterferon, about 1 unit/ml of interferon is the quantity necessary to produce a cytopathic effect of 50%. As there is no international Rat IFN-beta |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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