KRP334
甲硫氨酸氨基肽酶2, Methionine aminopeptidase 2 , MAP 2, MetAP 2, EC 3.4.11.18, Initiation factor 2-associated 67 kDa glycoprotein, p67, p67eIF2, Peptidase M, MNPEP, P67EIF2, Methionine aminopeptidase 2, MAP 2,
| Alias | 甲硫氨酸氨基肽酶2, Methionine aminopeptidase 2 , MAP 2, MetAP 2, EC 3.4.11.18, Initiation factor 2-associated 67 kDa glycoprotein, p67, p67eIF2, Peptidase M, MNPEP, P67EIF2, Methionine aminopeptidase 2, MAP 2, |
| Catalog Number | KRP334 |
| Molecular Name | METAP2 |
| Molecular Weight | 66 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥90% |
| Product Description | Human METAP2(Ala2-Tyr478) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.; Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. |
| Species | Human |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Measure by its ability to remove methionine from a fluorogenic peptide substrate HMet-Gly-ProAMC. The resulting GPAMC is cleaved by Recombinant Human DPPIV/CD26. The specific activity is >15 pmol/min/µg, as measured using the described conditions. |
| Uniprot ID | P50579-1 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | Sf9 |
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