Recombinant Mouse Leptin R Protein, C-His Tag
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产品编号
KRP329
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别名
瘦素受体, Leptin receptor , LEP-R, B219, OB receptor, OB-R, CD antigen CD295, Db, Obr, Leptin receptor, LEP-R,
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Alias | 瘦素受体, Leptin receptor , LEP-R, B219, OB receptor, OB-R, CD antigen CD295, Db, Obr, Leptin receptor, LEP-R, |
| Catalog Number | KRP329 |
| Molecular Name | Lepr |
| Molecular Weight | 130-140 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥90% |
| SDS-PAGE |  |
| Product Description | Mouse Lepr(Leu22-Gly839) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Receptor for hormone LEP/leptin (Probable) (PubMed:11861497). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS (PubMed:10799542, PubMed:11861497, PubMed:11923481, PubMed:25383904). In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:10660043, PubMed:12594516). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:11923481, PubMed:25383904). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis (PubMed:12594516). Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus (PubMed:25383904). Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (PubMed:9732873). {ECO:0000269|PubMed:10660043, ECO:0000269|PubMed:10799542, ECO:0000269|PubMed:11861497, ECO:0000269|PubMed:11923481, ECO:0000269|PubMed:12594516, ECO:0000269|PubMed:25383904, ECO:0000269|PubMed:9732873, ECO:0000305|PubMed:25232147}.; [Isoform A]: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis (PubMed:17620316, PubMed:20223942). Does not induce phosphorylation of and activate STAT3 (PubMed:11923481, PubMed:20223942). {ECO:0000269|PubMed:11923481, ECO:0000269|PubMed:17620316, ECO:0000269|PubMed:20223942}.; [Isoform E]: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis. {ECO:0000269|PubMed:17620316}. |
| Species | Mouse |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Measured by its ability to inhibit Leptindependent proliferation of BaF3 mouse pro‑B cells transfected with human Leptin R. The ED50 forthis effect is 2-10 ng/mL in the presence of 1 ng/mL recombinant mouse Leptin |
| Uniprot ID | P48356 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
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