Recombinant Mouse IL-15 Protein, C-His Tag_天津卡梅德科技发展有限公司

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Recombinant Mouse IL-15 Protein, C-His Tag

Recombinant Mouse IL-15 Protein, C-His Tag

产品编号

KRP328

别名

白细胞介素-15, Interleukin-15 , IL-15, Interleukin-15, IL-15,

规格

20ug
50ug
100ug
200ug
1mg

DATASHEET MSDS

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产品介绍

Alias	白细胞介素-15, Interleukin-15 , IL-15, Interleukin-15, IL-15,
Catalog Number	KRP328
Molecular Name	Il15
Molecular Weight	14 kDa
Size	20ug, 50ug, 100ug, 200ug, 1mg
Concentration	联系销售经理获得最新批次的浓度
Purity	≥95%
Product Description	Mouse Il15( 49-162 aa)
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Formulation	＜1.0EU/ug
Shipping Condition	This product is shipped on ice packs or dry ice.
Background	Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:11466332, PubMed:8757333). Stimulates the proliferation and activation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines (PubMed:8757333). In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection (By similarity). Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (PubMed:10882748, PubMed:19632221). {ECO:0000250\|UniProtKB:P40933, ECO:0000269\|PubMed:10882748, ECO:0000269\|PubMed:11466332, ECO:0000269\|PubMed:19632221, ECO:0000269\|PubMed:8757333}.
Species	Mouse
Purification	Affinity Purification
Endotoxin	Supplied in PBS
Biological Activity	Measured in a cell proliferation assay using HT-2 mouse T cells. The ED50 forthis effect is 15-58 ng/mL, corresponding to a specific activity of 1.72×10^4- 6.67×10^4 units/mg.
Uniprot ID	P48346
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。
Display Peptides	E. coli

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