Recombinant Mouse IL-15 Protein, C-His Tag
-
产品编号
KRP328
-
别名
白细胞介素-15, Interleukin-15 , IL-15, Interleukin-15, IL-15,
-
规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KRP328 |
| Alias | 白细胞介素-15, Interleukin-15 , IL-15, Interleukin-15, IL-15, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Mouse Il15( 49-162 aa) |
| Molecular Name | Il15 |
| Product Introduction | 白细胞介素-15通过促进免疫细胞增殖，调节免疫反应。。 |
| Molecular Weight | 14 kDa |
| Expression System | E. coli |
| Species | Mouse |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Purification | Affinity Purification |
| Uniprot ID | P48346 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:11466332, PubMed:8757333). Stimulates the proliferation and activation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines (PubMed:8757333). In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection (By similarity). Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (PubMed:10882748, PubMed:19632221). {ECO:0000250|UniProtKB:P40933, ECO:0000269|PubMed:10882748, ECO:0000269|PubMed:11466332, ECO:0000269|PubMed:19632221, ECO:0000269|PubMed:8757333}. |
| Endotoxin | ＜1.0EU/ug |
| Biological Activity | Measured in a cell proliferation assay using HT-2 mouse T cells. The ED50 forthis effect is 15-58 ng/mL, corresponding to a specific activity of 1.72×10^4- 6.67×10^4 units/mg. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
- 联系我们
- 电话：400-621-6806
- 手机：13116038708
- 邮箱：info@kmdbioscience.com
- 地址：天津市武清区国际企业社区A5栋
-
销售微信
-
官方公众号
-
400-621-6806 -
18630936064（微信同号） -
周一至周五 8:30-18:00 -
-
0
-
