KRP306
肿瘤坏死因子配体超家族成员6, Tumor necrosis factor ligand superfamily member 6 , CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL, CD antigen CD178, [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand
| Alias | 肿瘤坏死因子配体超家族成员6, Tumor necrosis factor ligand superfamily member 6 , CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL, CD antigen CD178, [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand |
| Catalog Number | KRP306 |
| Molecular Name | Faslg |
| Molecular Weight | 40-55 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Product Description | Mouse Faslg(101-279 aa) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:7511063). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:19794494, PubMed:7532682). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (PubMed:19794494). TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance (PubMed:10779162). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (By similarity). {ECO:0000250|UniProtKB:P48023, ECO:0000269|PubMed:19794494, ECO:0000269|PubMed:7511063, ECO:0000269|PubMed:7532682}.; [Tumor necrosis factor ligand superfamily member 6, soluble form]: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (PubMed:19794494). Can induce apoptosis but does not appear to be essential for this process (By similarity). {ECO:0000250|UniProtKB:P48023, ECO:0000269|PubMed:19794494}.; [FasL intracellular domain]: Cytoplasmic form induces gene transcription inhibition. {ECO:0000250|UniProtKB:P48023}. |
| Species | Mouse |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Immobilized Human Fas/CD95 hFcat 2 μg/mL (100 μL/well) can bind Human Fas Ligand His, the EC50 of Human Fas Ligand His is 40-200 ng/mL. |
| Uniprot ID | P41047 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
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