KRP304
血小板生成素受体, Thrombopoietin receptor , TPO-R, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD antigen CD110, TPOR, Thrombopoietin receptor, Myeloproliferative leukemia protein,
| Catalog Number | KRP304 |
| Alias | 血小板生成素受体, Thrombopoietin receptor , TPO-R, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD antigen CD110, TPOR, Thrombopoietin receptor, Myeloproliferative leukemia protein, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human MPL(26-491 aa) |
| Molecular Name | MPL |
| Product Introduction | 血小板生成素受体通过受体与细胞膜结合，调节血小板生成。。 |
| Molecular Weight | 68-70 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Purification | Affinity Purification |
| Uniprot ID | P40238 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K (PubMed:15899890, PubMed:37633268). In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production. {ECO:0000269|PubMed:15899890, ECO:0000269|PubMed:37633268}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to inhibit the Tpo-dependent proliferation of MO7e human megakaryocytic leukemic cells. The ED50 forthis effect is less than 5 µg/mL in the presence of 7.5 ng/mL ofrhTpo. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
销售微信
官方公众号
0
