KRP304
血小板生成素受体, Thrombopoietin receptor , TPO-R, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD antigen CD110, TPOR, Thrombopoietin receptor, Myeloproliferative leukemia protein,
| Alias | 血小板生成素受体, Thrombopoietin receptor , TPO-R, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD antigen CD110, TPOR, Thrombopoietin receptor, Myeloproliferative leukemia protein, |
| Catalog Number | KRP304 |
| Molecular Name | MPL |
| Molecular Weight | 68-70 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Product Description | Human MPL(26-491 aa) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K (PubMed:15899890, PubMed:37633268). In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production. {ECO:0000269|PubMed:15899890, ECO:0000269|PubMed:37633268}. |
| Species | Human |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Measured by its ability to inhibit the Tpo-dependent proliferation of MO7e human megakaryocytic leukemic cells. The ED50 forthis effect is less than 5 µg/mL in the presence of 7.5 ng/mL ofrhTpo. |
| Uniprot ID | P40238 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
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