KRP290
双特异性丝裂原活化蛋白激酶2, Dual specificity mitogen-activated protein kinase kinase 2 , MAP kinase kinase 2, MAPKK 2, EC 2.7.12.2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK 2, MEK2, MKK2, Dual specificity mitogen-activated protein kinase kinase 2, MAPKK 2,
| Catalog Number | KRP290 |
| Alias | 双特异性丝裂原活化蛋白激酶2, Dual specificity mitogen-activated protein kinase kinase 2 , MAP kinase kinase 2, MAPKK 2, EC 2.7.12.2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK 2, MEK2, MKK2, Dual specificity mitogen-activated protein kinase kinase 2, MAPKK 2, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human MAP2K2(1-400 aa) |
| Molecular Name | MAP2K2 |
| Product Introduction | 双特异性丝裂原活化蛋白激酶2调节细胞信号传导，促进细胞增殖与分化。。 |
| Molecular Weight | 71 kDa |
| Expression System | sf9 |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥90% |
| Purification | Affinity Purification |
| Uniprot ID | P36507 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | The specific activity of MEK2 was determined to be 190 nmol/min/mg as per activity assay protocol. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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