KRP281
细胞因子受体共同亚单位beta, Cytokine receptor common subunit beta , CDw131, GM-CSF/IL-3/IL-5 receptor common beta subunit, CD antigen CD131, IL3RB, IL5RB, Cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta subunit,
| Alias | 细胞因子受体共同亚单位beta, Cytokine receptor common subunit beta , CDw131, GM-CSF/IL-3/IL-5 receptor common beta subunit, CD antigen CD131, IL3RB, IL5RB, Cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta subunit, |
| Catalog Number | KRP281 |
| Molecular Name | CSF2RB |
| Molecular Weight | 55-65 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Product Description | Human CSF2RB(17-443 aa) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:9516124}. |
| Species | Human |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Immobilized human CD131 at 10 μg/ml (100 μl/well) can bind human FcGMCSF, The EC50 of human Fc-GMCSF is 250- 500 ng/ml. |
| Uniprot ID | P32927-1 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
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