KRP270
Ephrin类型A受体8, Ephrin type-A receptor 8 , EC 2.7.10.1, EPH- and ELK-related kinase, EPH-like kinase 3, EK3, hEK3, Tyrosine-protein kinase receptor EEK, EEK, HEK3, Ephrin type-A receptor 8, EPH- and ELK-related kinase,
| Alias | Ephrin类型A受体8, Ephrin type-A receptor 8 , EC 2.7.10.1, EPH- and ELK-related kinase, EPH-like kinase 3, EK3, hEK3, Tyrosine-protein kinase receptor EEK, EEK, HEK3, Ephrin type-A receptor 8, EPH- and ELK-related kinase, |
| Catalog Number | KRP270 |
| Molecular Name | EPHA8 |
| Molecular Weight | 94 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥90% |
| SDS-PAGE |  |
| Product Description | Human EPHA8(31-542 aa) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). {ECO:0000250}. |
| Species | Human |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Measured by its binding ability in a functional ELISA. When Recombinant Human EphA8 Fc Chimera is coated at 2 μg/mL (100 μL/well), the concentration of Biotinylayed Recombinant Human Ephrin-A5 Fc Chimera that produces 50% of the optimal binding response i |
| Uniprot ID | P29322 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
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