KRP254
NKG2-C型II整合膜蛋白, NKG2-C type II integral membrane protein , CD159 antigen-like family member C, NK cell receptor C, NKG2-C-activating NK receptor, CD antigen CD159c, NKG2C, NKG2-C type II integral membrane protein, NK cell receptor C,
| Catalog Number | KRP254 |
| Alias | NKG2-C型II整合膜蛋白, NKG2-C type II integral membrane protein , CD159 antigen-like family member C, NK cell receptor C, NKG2-C-activating NK receptor, CD antigen CD159c, NKG2C, NKG2-C type II integral membrane protein, NK cell receptor C, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human KLRC2(98-231 aa) |
| Molecular Name | KLRC2 |
| Product Introduction | NKG2-C型II整合膜蛋白在NK细胞的激活过程中，起到信号转导作用。。 |
| Molecular Weight | 53-62 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE | |
| Purification | Affinity Purification |
| Uniprot ID | P26717 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy (PubMed:30134159, PubMed:37264229, PubMed:9754572). Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PubMed:20952657, PubMed:21825173). Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PubMed:15940674, PubMed:9655483). {ECO:0000269|PubMed:15940674, ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:21825173, ECO:0000269|PubMed:30134159, ECO:0000269|PubMed:37264229, ECO:0000269|PubMed:9655483, ECO:0000269|PubMed:9754572}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to bind Recombinant Human CD94 in a functional ELISA. The ED50 forthis effect is 0.3‑2.4 µg/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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