KRP236
白细胞介素-6受体亚单位alpha, Interleukin-6 receptor subunit alpha , IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, CD antigen CD126, [Cleaved into: Soluble interleukin-6 receptor subunit alpha , sIL6R, ], Il6r, Interleukin-6 recepto
| Alias | 白细胞介素-6受体亚单位alpha, Interleukin-6 receptor subunit alpha , IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1, CD antigen CD126, [Cleaved into: Soluble interleukin-6 receptor subunit alpha , sIL6R, ], Il6r, Interleukin-6 recepto |
| Catalog Number | KRP236 |
| Molecular Name | Il6ra |
| Molecular Weight | 60-66 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥90% |
| SDS-PAGE |  |
| Product Description | Mouse Il6ra(Leu20-Glu357) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. {ECO:0000305|PubMed:30995492}.; [Interleukin-6 receptor subunit alpha]: Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory (Probable). Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells (PubMed:27893700). {ECO:0000269|PubMed:27893700, ECO:0000305|PubMed:30995492}.; [Soluble interleukin-6 receptor subunit alpha]: Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity (PubMed:11113088). The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases (By similarity). In complex with IL6, is required for induction of VEGF production (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (PubMed:11113088). 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis (PubMed:28402851). {ECO:0000250|UniProtKB:P08887, ECO:0000269|PubMed:11113088, ECO:0000269|PubMed:28402851}. |
| Species | Mouse |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Measured by its binding ability in a functional ELISA. When Recombinant Mouse IL-6 Protein is immobilized at 2.00 μg/mL, 100 μL/well, Recombinant Mouse IL-6R alpha Protein binds with an ED50 of 30.0- 300 ng/mL. |
| Uniprot ID | P22272 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
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