Recombinant Human BMP5 Protein, C-His Tag
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产品编号
KRP235
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别名
骨形态发生蛋白5, Bone morphogenetic protein 5 , BMP-5, Bone morphogenetic protein 5, BMP-5,
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KRP235 |
| Alias | 骨形态发生蛋白5, Bone morphogenetic protein 5 , BMP-5, Bone morphogenetic protein 5, BMP-5, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human BMP5(317-454 aa) |
| Molecular Name | BMP5 |
| Product Introduction | 骨形态发生蛋白5参与骨形态发生与修复过程的蛋白。。 |
| Molecular Weight | 18-23 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| Purification | Affinity Purification |
| Uniprot ID | P22003 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:11580864, PubMed:29321139). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:11580864). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:11580864, PubMed:29321139). Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed:20402566). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509). {ECO:0000269|PubMed:11580864, ECO:0000269|PubMed:20402566, ECO:0000269|PubMed:29321139, ECO:0000269|PubMed:30097509}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 forthis effect is 0.2‑1.2 µg/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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