Recombinant Human BMP5 Protein, C-His Tag_天津卡梅德科技发展有限公司

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Recombinant Human BMP5 Protein, C-His Tag

Recombinant Human BMP5 Protein, C-His Tag

产品编号

KRP235

别名

骨形态发生蛋白5, Bone morphogenetic protein 5 , BMP-5, Bone morphogenetic protein 5, BMP-5,

规格

20ug
50ug
100ug
200ug
1mg

DATASHEET MSDS

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产品介绍

Alias	骨形态发生蛋白5, Bone morphogenetic protein 5 , BMP-5, Bone morphogenetic protein 5, BMP-5,
Catalog Number	KRP235
Molecular Name	BMP5
Molecular Weight	18-23 kDa
Size	20ug, 50ug, 100ug, 200ug, 1mg
Concentration	联系销售经理获得最新批次的浓度
Purity	≥95%
Product Description	Human BMP5(317-454 aa)
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Formulation	< 0.1 EU per ug
Shipping Condition	This product is shipped on ice packs or dry ice.
Background	Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:11580864, PubMed:29321139). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:11580864). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:11580864, PubMed:29321139). Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed:20402566). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509). {ECO:0000269\|PubMed:11580864, ECO:0000269\|PubMed:20402566, ECO:0000269\|PubMed:29321139, ECO:0000269\|PubMed:30097509}.
Species	Human
Purification	Affinity Purification
Endotoxin	Supplied in PBS
Biological Activity	Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 forthis effect is 0.2‑1.2 µg/mL.
Uniprot ID	P22003
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。
Display Peptides	HEK293F Cells

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