KRP228
Kit配体（肥大细胞生长因子）, Kit ligand , Mast cell growth factor, MGF, Stem cell factor, SCF, c-Kit ligand, [Cleaved into: Soluble KIT ligand , sKITLG, ], MGF, SCF, Kit ligand, Mast cell growth factor (MGF),
| Catalog Number | KRP228 |
| Alias | Kit配体（肥大细胞生长因子）, Kit ligand , Mast cell growth factor, MGF, Stem cell factor, SCF, c-Kit ligand, [Cleaved into: Soluble KIT ligand , sKITLG, ], MGF, SCF, Kit ligand, Mast cell growth factor (MGF), |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Human KITLG(26-189 aa) |
| Molecular Name | KITLG |
| Product Introduction | Kit配体（肥大细胞生长因子）通过与肥大细胞生长因子结合，促进免疫调节。。 |
| Molecular Weight | 22 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | P21583-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 forthis effect is 1.00-8.00 ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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