KRP210
类胰岛素生长因子结合蛋白2, Insulin-like growth factor-binding protein 2 , IBP-2, IGF-binding protein 2, IGFBP-2, BP2, IBP2, Insulin-like growth factor-binding protein 2, IGF-binding protein 2,
| Alias | 类胰岛素生长因子结合蛋白2, Insulin-like growth factor-binding protein 2 , IBP-2, IGF-binding protein 2, IGFBP-2, BP2, IBP2, Insulin-like growth factor-binding protein 2, IGF-binding protein 2, |
| Catalog Number | KRP210 |
| Molecular Name | IGFBP2 |
| Molecular Weight | 60-70 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Product Description | Human IGFBP2(Glu40-Gln328) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | < 0.1 EU per ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18563800, PubMed:38796567). Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation (PubMed:22869525). Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif (PubMed:16569642). Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells (PubMed:26076738). Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury (PubMed:38796567). {ECO:0000269|PubMed:16569642, ECO:0000269|PubMed:18563800, ECO:0000269|PubMed:19081843, ECO:0000269|PubMed:22869525, ECO:0000269|PubMed:26076738, ECO:0000269|PubMed:38796567}. |
| Species | Human |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Immobilized Recombinant Human IGFBP-2 at 5 μg/mL (100 μL/well) can bind Recombinant Human IGF1 with a linear range of 50-220 ng/mL. |
| Uniprot ID | P18065 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
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