KRP203
肿瘤坏死因子, Tumor necrosis factor , Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, [Cleaved into: Tumor necrosis factor, membrane form , N-terminal fragment, NTF, ; Intracellular domain 1 , ICD1, ; Intracellular domain 2 , ICD
| Alias | 肿瘤坏死因子, Tumor necrosis factor , Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, [Cleaved into: Tumor necrosis factor, membrane form , N-terminal fragment, NTF, ; Intracellular domain 1 , ICD1, ; Intracellular domain 2 , ICD |
| Catalog Number | KRP203 |
| Molecular Name | Tnf |
| Molecular Weight | 18 kDa |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Product Description | Rat Tnf(Leu80-Leu235) |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | ＜1.0EU/ug |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity). {ECO:0000250|UniProtKB:P01375, ECO:0000250|UniProtKB:P06804}.; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. {ECO:0000250|UniProtKB:P01375}. |
| Species | Rat |
| Purification | Affinity Purification |
| Endotoxin | Supplied in PBS |
| Biological Activity | Measured in a cytotoxicity assay using L-929 mouse fibrosarcoma cells in the presence of metabolic inhibitor actinomycin D.The ED50 for this effect is typically 0.0125-0.05 pg/mL.. |
| Uniprot ID | P16599 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Display Peptides | HEK293F Cells |
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