KRP187
C-C基序趋化因子2, C-C motif chemokine 2 , Immediate-early serum-responsive protein JE, Monocyte chemoattractant protein 1, Monocyte chemotactic protein 1, MCP-1, Small-inducible cytokine A2, Je, Mcp1, Scya2,
| Catalog Number | KRP187 |
| Alias | C-C基序趋化因子2, C-C motif chemokine 2 , Immediate-early serum-responsive protein JE, Monocyte chemoattractant protein 1, Monocyte chemotactic protein 1, MCP-1, Small-inducible cytokine A2, Je, Mcp1, Scya2, |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Rat Ccl2(24-148 aa) |
| Molecular Name | Ccl2 |
| Product Introduction | C-C基序趋化因子2调节单核细胞的趋化，参与免疫反应。。 |
| Molecular Weight | 25-35 kDa |
| Expression System | HEK293F Cells |
| Species | Rat |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥90% |
| SDS-PAGE | |
| Purification | Affinity Purification |
| Uniprot ID | P14844 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). {ECO:0000250|UniProtKB:P10148, ECO:0000250|UniProtKB:P13500}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CCR2A. The ED50 forthis effect is 30-150 ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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