KRP174
白细胞介素-1受体1型, Interleukin-1 receptor type 1 , IL-1R-1, IL-1RT-1, IL-1RT1, EC 3.2.2.6, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type I, p80, CD antigen CD121a, [Cleaved into: Interleukin-1 recepto
| Catalog Number | KRP174 |
| Alias | 白细胞介素-1受体1型, Interleukin-1 receptor type 1 , IL-1R-1, IL-1RT-1, IL-1RT1, EC 3.2.2.6, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type I, p80, CD antigen CD121a, [Cleaved into: Interleukin-1 recepto |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Mouse Il1r1(Leu20 - Lys338) |
| Molecular Name | Il1r1 |
| Product Introduction | 白细胞介素-1受体1型白细胞介素-1的受体，参与炎症反应的调节。。 |
| Molecular Weight | 55-60 kDa |
| Expression System | HEK293F Cells |
| Species | Mouse |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥90% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | P13504-1 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity). {ECO:0000250|UniProtKB:P14778}.; [Isoform 2]: Unable to mediate canonical IL-1 signaling. Cooperates with IL1RAP isoform 3 to mediate IL1B-induced neuronal activity including IL1B-potentiated NMDA-induced calcium influx mediated by Akt kinase activation. {ECO:0000269|PubMed:22778412}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to inhibit IL-1 alpha - dependent proliferation in D10.G4.1 mouse helper T cells. Approximately 0.005‑0.015 µg/mL of IL-1 sRI will inhibit 50% of the biological response due to 50 pg/mL of rmIL-1a |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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